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| 22KS-027 |
The Efficacy and Safety of atelocollagen for Patients with Rotator Cuff Tear compared with Prolotherapy
Department of Anesthesiology and
Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Background
Atelocollagen (Tendoregen®) is made after pepsin treatment to remove the C-terminal and N-terminal for alleviating of immunogenicity. Atelocollagen injection therapy has been proven to be effective in pain relief and functional improvement of patients with rotator cuff partial tears (RCPT) in previous studies. We evaluated the difference clinical effectiveness and reduction of tear size between atelocollagen injection and prolotherapy in patients with RCPT.
Methods
A total of 34 patients with RCPT in MRI were randomized into either the atelocollagen injection group (C group=17) or the prolotherapy group (P group=17). In each group, three times injections (1ml of atelocollagen with 1% lidocaine or 1ml of 20% dextrose with 1% lidocaine) were performed at intervals of a week, and the clinical effectiveness (shoulder pain, patient’s satisfaction, Korean Shoulder Pain and Disability, K-SPADI) of injections were evaluated at 4 and 12 weeks after last injections. Follow-up MRI was performed at 12 weeks after last injection to analyze the reduction of tear size and improvement inflammation at site of RCPT. Also, we collected age, gender, weight, height and underlying diseases.
Results
Finally, 30 patients (C group=16 and P group=14) were analyzed and completed the follow-up MRI (Table 1). There was no difference in shoulder pain, patient’s satisfaction and K-SPADI between the both groups. The improvement state of RCPT in follow-up MRI was observed 4 patients (25%) of only C group, but there was no one in P group.
Conclusion
Atelocollagen injection in patients with RCPT may contribute to a reduction in tear size and reduced inflammation in some patients. It will be needed to establish the indications for which atelocollagen injection can be effective in patients with RCPT.
mographics and characteristics between atelocollagen injection group (C group) and the prolotherapy group (P group).
Characteristic C group
(n = 16) P group
(n = 14) P values
Sex (M/F) 5/11 5/9 0.79
Age (years) 60.7 ± 9.0 57.9 ± 7.6 0.36
Height (cm) 160.2 ± 7.5 164.1 ± 8.3 0.19
Weight (kg) 62.7 ± 12.6 70.9 ± 9.0 0.06
DM 3 4
Depression 1 4
Tear site of RCPT* in MRI 0.83
Bursa side, n (%) 7 (43.7) 5 (35.7)
Intratendinous, n (%) 7 (43.7) 7 (50)
Articular side, n (%) 2 (12.6) 2 (14.3)
*RCPT : rotator cuff partial tears
Atelocollagen (Tendoregen®) is made after pepsin treatment to remove the C-terminal and N-terminal for alleviating of immunogenicity. Atelocollagen injection therapy has been proven to be effective in pain relief and functional improvement of patients with rotator cuff partial tears (RCPT) in previous studies. We evaluated the difference clinical effectiveness and reduction of tear size between atelocollagen injection and prolotherapy in patients with RCPT.
Methods
A total of 34 patients with RCPT in MRI were randomized into either the atelocollagen injection group (C group=17) or the prolotherapy group (P group=17). In each group, three times injections (1ml of atelocollagen with 1% lidocaine or 1ml of 20% dextrose with 1% lidocaine) were performed at intervals of a week, and the clinical effectiveness (shoulder pain, patient’s satisfaction, Korean Shoulder Pain and Disability, K-SPADI) of injections were evaluated at 4 and 12 weeks after last injections. Follow-up MRI was performed at 12 weeks after last injection to analyze the reduction of tear size and improvement inflammation at site of RCPT. Also, we collected age, gender, weight, height and underlying diseases.
Results
Finally, 30 patients (C group=16 and P group=14) were analyzed and completed the follow-up MRI (Table 1). There was no difference in shoulder pain, patient’s satisfaction and K-SPADI between the both groups. The improvement state of RCPT in follow-up MRI was observed 4 patients (25%) of only C group, but there was no one in P group.
Conclusion
Atelocollagen injection in patients with RCPT may contribute to a reduction in tear size and reduced inflammation in some patients. It will be needed to establish the indications for which atelocollagen injection can be effective in patients with RCPT.
mographics and characteristics between atelocollagen injection group (C group) and the prolotherapy group (P group).
Characteristic C group
(n = 16) P group
(n = 14) P values
Sex (M/F) 5/11 5/9 0.79
Age (years) 60.7 ± 9.0 57.9 ± 7.6 0.36
Height (cm) 160.2 ± 7.5 164.1 ± 8.3 0.19
Weight (kg) 62.7 ± 12.6 70.9 ± 9.0 0.06
DM 3 4
Depression 1 4
Tear site of RCPT* in MRI 0.83
Bursa side, n (%) 7 (43.7) 5 (35.7)
Intratendinous, n (%) 7 (43.7) 7 (50)
Articular side, n (%) 2 (12.6) 2 (14.3)
*RCPT : rotator cuff partial tears
