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| 22KS-021 |
Effect of Pregabalin Combined with Duloxetine and Tramadol on Allodynia in Chronic Postischemic Pain Mouse Models
Department of Anesthesiology and Pain Medicine, Seoul St Marys Hospital College of Medicine, Korea
1. Introduction
Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory nervous system and has an important impact on quality of life. The pathogenesis of NP is complicated. Various studies proposed that pathophysiological mechanisms related to neurogenic inflammation and central sensitization contribute to NP. However, NP may result from the combination of multiple mechanisms. Due to this diversity of mechanisms, NP is difficult to treat, mainly because common analgesics have poor therapeutic efficacy against this disease
Pregabalin, duloxetine, and tramadol all have a certain ability to relieve NP, but these effects are not obvious when they are used individually. There are few reports on the effects of different combinations of pregabalin, duloxetine, and tramadol. This study evaluated the effects of the combinations of these three drugs in two animal models, namely,
a chronic postischemic pain (CPIP) model and a spinal nerve ligation (SNL) model, to identify a drug combination with enhanced efficacy and fewer side effects such as dizziness, drowsiness, and motor weakness for development as a novel therapeutic strategy
2. Conclusion
A combination of pregabalin, duloxetine, and tramadol produced an anti-allodynic effect in CPIP and SNL model mice, as indicated by a behavioral test, and inhibited astrocytes, as shown by immunohistochemistry. The enhanced efficacy and decreased side effects such as dizziness, drowsiness, and motor weakness for these
combinations will aid physicians in clinical treatment. Further investigations are needed in the clinical setting.
Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory nervous system and has an important impact on quality of life. The pathogenesis of NP is complicated. Various studies proposed that pathophysiological mechanisms related to neurogenic inflammation and central sensitization contribute to NP. However, NP may result from the combination of multiple mechanisms. Due to this diversity of mechanisms, NP is difficult to treat, mainly because common analgesics have poor therapeutic efficacy against this disease
Pregabalin, duloxetine, and tramadol all have a certain ability to relieve NP, but these effects are not obvious when they are used individually. There are few reports on the effects of different combinations of pregabalin, duloxetine, and tramadol. This study evaluated the effects of the combinations of these three drugs in two animal models, namely,
a chronic postischemic pain (CPIP) model and a spinal nerve ligation (SNL) model, to identify a drug combination with enhanced efficacy and fewer side effects such as dizziness, drowsiness, and motor weakness for development as a novel therapeutic strategy
2. Conclusion
A combination of pregabalin, duloxetine, and tramadol produced an anti-allodynic effect in CPIP and SNL model mice, as indicated by a behavioral test, and inhibited astrocytes, as shown by immunohistochemistry. The enhanced efficacy and decreased side effects such as dizziness, drowsiness, and motor weakness for these
combinations will aid physicians in clinical treatment. Further investigations are needed in the clinical setting.
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