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21KF-040
Analgesic effect of Panaphix in nociceptive pain models of Rats

Kyunghwan Jang1, Doo-hwan Kim1, Jin-Woo Shin1, Seong-Soo Choi1

1Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Background
Panaphix (PAX-1, sodium meta-arsenite or NaAsO2) is developed as a therapy for the treatment of various cancer and is known to have analgesic effects. The present study was aimed to investigate the analgesic effects of PAX-1 on nociception in rats.


Methods
The analgesic effect of PAX-1 on nociception was measured using the hot (52.5°C) and cold (2°C) plate test, and surgical incision. Six rats were divided into five groups, respectively; vehicle, 0.1, 1.0, and 10.0 mg/kg of PAX-1, and sham. PAX-1 was orally administered for a week before the hot and cold plate test, and a week after surgery for the treatment of surgical incisional nociception. The analgesic effect was evaluated by measuring the withdrawal threshold to a Von Frey filament in surgical incision group.


Results
Latency of the hot (vehicle vs. 0.1, 1.0, and 10 mg/kg of PAX-1; P=0.008, P=0.006, and P<0.001) and cold plate (vehicle vs. 1.0 and 10 mg/kg of PAX-1; P<0.001, and P<0.001) was significantly prolonged in PAX-1 groups than in vehicle. Compared to vehicle, the Von Frey values were significantly increased in PAX-1 groups when surgical incision test (postoperative day (POD) 1: vehicle vs. 10mg/kg of PAX-1, P=0.002; POD3: vehicle vs. 1.0 and 10 mg/kg of PAX-1, P<0.001 and P=0.008; POD7: vehicle vs. 0.1, 1.0 and 10 mg/kg of PAX-1, P<0.001 in all).


Conclusion
PAX-1 showed preventive and therapeutic effects for incision-evoked mechanical nociception and reduced heat and cold nociception in a rat model, suggesting PAX-1 may have analgesic effects for nociceptive pain.